Effects of prostaglandins and indomethacin on neuromuscular blocking agents
نویسندگان
چکیده
منابع مشابه
Effects of prostaglandins and indomethacin on neuromuscular blocking agents.
The effects on neuromuscular blockade by d-tubocurarine and succinylcholine of inhibition of prostaglandin biosynthesis by indomethacin and of intra-arterial administration of prostoglandins E2 and F2 alpha, before and after inhibition of prostoglandin biosynthesis, were evaluated in the cat sciatic-tibialis preparation. Non-specific inhibition of prostaglandin biosynthesis by indomethacin 3 mg...
متن کاملEFFECTS OF CHRONIC ADMINISTRATION OF TWO NEWLY SYNTHESIZED NONDEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS
The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...
متن کاملNeuromuscular Blocking Agents
• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...
متن کاملNeuromuscular blocking agents: a review.
The author provides a review of the mechanism of neuromuscular transnission, as well as the Nechanisn of action and differences between curare and succinylcholine. Effects of these two relaxants on various organs and tissues are discussed, as are their onset of action, duration, elimination, and clinical uses. In order to understand how skeletal muscle re-laxants act, the mechanism of neuromusc...
متن کاملIndications for Neuromuscular Blocking Agents
©International Anesthesia Research Society. Unauthorized Use Prohibited. Almost thirty years ago, residual neuromuscular blockade was documented in a surprisingly high proportion of patients (30%), despite an almost systematic use of anticholinesterase agents.1 Since then, even with the development of shorter-acting neuromuscular blockers, pharmacological reversal, and more widespread use of ne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1980
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03007777